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Interestingly, we also found that the hypoxia-induced decline in PP2A activity was reversed when -syn or p--syn was interfered with, suggesting that hypoxia-induced PP2A inhibition and -syn pathology are mutually reinforcing vicious cycles

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They also hypothesized that autophagy associated with COVID-19, FLT3-ITD, and overexpression of HIF-1 may cause leukemia and drug resistance in these patients